Lipid droplet associated proteins are critical regulators of metabolic health (#27)
Lipid droplets containing triglyceride are present in most cells of the body and are a critical regulatory point for metabolic control. It is two decades since the discovery of perilipin 1, which is a lipid droplet associated protein that is essential for the maintenance of efficient triglyceride breakdown in adipose tissue. Since then, other members of the perilipin family (denoted PLIN2, 3, 4 and 5) have been discovered and regulate lipid metabolism, most prominently in the muscle and liver. This presentation will describe the major recent advances in the understanding of perilipin family member functions with a focus on lipid metabolism and the subsequent impact on insulin action.